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As co-regulated genes share some similarities in their regulatory mechanism, possibly at transcriptional level, their promoter regions may contain common motifs that are binding sites for transcription regulators [ 23 ]. Given a cluster of endometrial regulated genes with similar expression profiles, the characterization of their regulatory regions is a fundamental step toward understanding the largely unexplored networks of gene regulation in this complex tissue responsible for their coordinated behavior. Computation biology of gene regulation offers several bioinformatic tools developed for the prediction of TFBS within a specific regulatory DNA sequence [ 24 ]. Given a set of co-regulated transcripts, in silico predictions of TFBS in their regulatory regions offers a unique opportunity to identify novel components, leading to the formulation of transcriptional regulatory networks hypotheses that can be further tested in the wet laboratory. The aim of this study was to increase our understanding of endometrial receptivity to embryo implantation, by performing a research synthesis of the grundwissen mathematikstudium rezension allegra available DNA microarray data. The first objective was to determine genes consistently reported in the literature as allegra dress misha collection jumpsuit up- or down-regulated from pre receptive to the receptive endometrium.

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